Human body age can be determined by gut microbiome

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Human body age can be determined by gut microbiome

Chinese researchers suggest that a person’s gut microbiota is a key factor in determining their age.

The gut microbiota has been found to play a significant role in estimating an individual’s age based on a hypothesis from Chinese researchers.

According to a new study that was published in the journal Nature Medicine, they also demonstrated its potential influence on controlling metabolic aging, as reported by CGTN.

The study states that understanding the relationships between the gut microbiome, metabolism, and aging is essential for developing therapies targeted at promoting healthy longevity.

Human body age can be determined by gut microbiome

Shanghai Jiao Tong University School of Medicine and BGI Research collaborated with Ruijin Hospital researchers to perform a study on 10,207 people between the ages of 40 and 93.

Using 21 metabolic markers, or what are known as metabolic multimorbidity clusters—distinct metabolic subphenotypes—they grouped those people into five groups.

In comparison to the cluster designated as metabolically healthy, the “obesity-related mixed” and “hyperglycemia” clusters showed a higher 11.1-year risk of cardiovascular disease by 75% and 117%, respectively.

These correlations were confirmed in a second sample of 9,061 people with a 10-year follow-up.

After conducting a thorough examination of the fecal metagenomic data of 4,491 randomly chosen individuals, the researchers discovered a correlation between age and the gut microbial composition and metabolic multimorbidity clusters.

Furthermore, as the data suggests, gut microbial age as a biomarker may be a promising predictor of cardiovascular disease risk.

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